From discovery to translation: Endogenous substrates of OAT1 and OAT3 as clinical biomarkers for renal secretory function
Aarzoo Thakur, Dilip Kumar Singh, Katherine D. Hart, Emese Kis, Zsuzsanna Gáborik, Travis T. Denton, John Clarke, Mary F. Paine, Bhagwat Prasad
This paper identifies 23 endogenous substrates of OAT1/3 as clinical biomarkers for renal secretory function, enabling prediction of drug interactions and interindividual variability.
Clinical Pharmacology & Therapeutics · May 22, 2025Peer-reviewedPharmacology & Toxicology