Bhagwat Prasad

This study evaluates how prenatal betamethasone exposure and tubular maturation affect gentamicin-induced kidney injury and nephron number in rats.

This study investigates how chronic alcohol exposure increases CYP3A enzyme activity in human liver microsomes through interactions with CYP2E1, despite no change in CYP3A levels.

This study investigates the molecular effects of prenatal cannabis exposure on human fetal brains, finding significant disruptions in male second trimester brains linked to neurodevelopmental disorders.

This paper introduces a new fluorogenic substrate, MONA, for CYP1A2 and uses it to study how chronic alcohol exposure affects CYP1A2 activity in human liver microsomes.

This paper identifies 23 endogenous substrates of OAT1/3 as clinical biomarkers for renal secretory function, enabling prediction of drug interactions and interindividual variability.

This study investigates how cimetidine affects metformin's pharmacokinetics by inhibiting OCT1 and OCT2, showing increased plasma exposure and reduced renal clearance.

This study investigates how alcohol consumption and smoking affect drug-metabolizing enzymes and transporters in human liver microsomes, identifying significant changes in enzyme abundance and proposing an alcohol exposure index.

The paper investigates how alcohol affects drug metabolism by analyzing interactions between P450 enzymes in human liver microsomes, finding alcohol increases low-affinity enzyme roles and alters enzyme-specific metabolic rates.

This study compares transcriptomes of in vitro human placental models to bulk placental tissue, finding significant gene expression differences and developing a web tool for model selection.