Hypothalamic Farnesoid X Receptor deficiency alters energy balance by modulating hepatic glucose production and adipose tissue metabolism through central insulin signaling.
Chloé Blondel, Cyril Bourouh, Emilie Nicolas, Aurélie Vadel, Emilie Dorchies, Emmanuelle Vallez, Anne Tailleux, Sophie Lestavel, Bart Staels, Kadiombo Bantubungi
This study shows that hypothalamic FXR deficiency leads to positive energy balance by altering glucose metabolism and adipose tissue structure.
bioRxiv · Sep 28, 2026 · PreprintPhysiology