Bart Staels

Rev-erb-alpha inhibits vascular calcification by repressing osteogenic reprogramming in atherosclerosis

This study identifies Rev-erb-alpha as a repressor of vascular calcification by inhibiting osteogenic reprogramming of vascular smooth muscle cells in atherosclerosis.

The constitutive androstane receptor protects against metabolic dysfunction-associated steatotic liver disease through sex specific interactions with the gut microbiota

This study shows that the constitutive androstane receptor (CAR) protects against MASLD in males through interactions with gut microbiota, but not in females.

PPARα-dependent effects in the liver and jejunum of mice in response to pemafibrate

This study examines pemafibrate's tissue-specific transcriptional effects in PPAR-dependent mice, showing strong responses in liver and jejunum but not in other tissues.

Experimental and mathematical models reveal that AMPK modulates circadian clock gene expression and period through NAD+-dependent regulation of Bmal1

The paper shows that AMPK modulates circadian clock period and Bmal1 expression through NAD+-dependent mechanisms, validated by experiments and mathematical modeling.

Hypothalamic Farnesoid X Receptor deficiency alters energy balance by modulating hepatic glucose production and adipose tissue metabolism through central insulin signaling.

This study shows that hypothalamic FXR deficiency leads to positive energy balance by altering glucose metabolism and adipose tissue structure.

Hepatic stellate cell FXR signaling regulates context-dependent functions in liver homeostasis and fibrosis.

The paper investigates the role of FXR signaling in hepatic stellate cells (HSCs) during liver homeostasis and fibrosis, showing its impact on gene expression and anti-fibrotic effects.

Accurate and memory-efficient cell type annotation from multimodal single-cell RNA and protein data

pyODIN improves cell type annotation by integrating RNA and protein data, achieving higher accuracy and resolving finer cell subtypes than existing methods.

Deep learning models reading clinical data and liver omics strongly distinguish NASH from steatosis and suggest new genes involved in liver disease severity

The paper develops a deep learning model combining clinical data, gene expression, and DNA methylation to distinguish NASH from steatosis and identifies new genes involved in liver disease severity.

The Circadian Clock Controls Hepatic Stellate Cell Activation in Liver Fibrosis via a BMAL1/CK1ϵ/REV-ERBα/Transgelin Signaling Pathway.

This study identifies a circadian clock-controlled signaling pathway that drives hepatic stellate cell activation in liver fibrosis, offering potential drug targets and a basis for chronotherapeutic strategies.

Mechanistic Heterogeneity in Type 2 Diabetes and Hypertension Comorbidity Revealed with Partitioned Polygenic Scores

The paper identifies genetic clusters underlying T2D and hypertension comorbidity using partitioned polygenic scores, improving risk prediction for individuals with heightened susceptibility.

Crosstalk interactions between transcription factors ERRalpha and PPARalpha assist PPARalpha-mediated gene expression

The paper identifies crosstalk between ERRalpha and PPARalpha transcription factors, showing ERRalpha can act as both a repressor and activator of PPARalpha-mediated gene expression.

CytoBatchNorm: an R package with graphical interface for batch effects correction of cytometry data

The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogramming

This study shows that HDAC inhibition by trichostatin A disrupts β-cell function and identity through epigenome-wide remodeling in both mouse and human β-cell models.

Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients

The paper examines time-of-day-dependent transcriptome and metabolome variations in human NAFL and NASH livers, finding disruptions in rhythmic gene expression and metabolites.

A time- and space-resolved nuclear receptor atlas in mouse liver

This paper maps nuclear receptor expression in mouse liver across time and space using single-cell RNAseq data.