C1q in non-immune human serum has a non-redundant complement function towards clinical Mycobacterium tuberculosis complex strains
Mario Alejandro Duque, Maximilian Peter Götz, Emilie Rousseau, Susanne Homolka, Stefan Niemann, Peter Garred, Christoph Hölscher, Kerstin Walter, Anne Rosbjerg
This study shows that C1q from the classical complement pathway, along with MBL from the lectin pathway, recognizes MTBC strains, with C1q playing a key role in complement activation.
bioRxiv · Nov 1, 2024 · PreprintImmunology