Disruption of NUAK2-Mediated RNA Splicing by Trilaciclib Reveals a Therapeutic Vulnerability in AR-Indifferent Prostate Cancer
Umar Mehraj, Uran Maimekov, Shaista Manzoor, Emily Cordova, Manasiben Patel, Ikeer Y. Mancera-Ortiz, Stefanie Howell, Zachary W. Davis‐Gilbert, Mu‐En Wang, Ming Chen, Jung Wook Park, Yuzhuo Z. Wang, Jasmine Plummer, Andrew J Armstrong, Jiaoti Huang, , Everardo Macias
This paper identifies NUAK2 as a therapeutic target in AR-indifferent prostate cancer, showing trilaciclib inhibits NUAK2 and suppresses tumor growth.
bioRxiv · Nov 12, 2025 · PreprintCancer Biology