Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation
Feda H. Hamdan, Mona Farhadipour, Isaiah Pérez, Kimberlee F. Kossick, Hannah Smith, Adam L. Edwinson, José M. de Hoyos‐Vega, Michelle M. Gonzalez, David Chiang, Emily E. Klatt, Kristy Rumer, Mauricio E. Perez, Mary R. Sagstetter, Jessica J. Friton, Erin Kammer, , Brooke R. Druliner
This study shows that intestinal stem cells from IBD patients retain epigenetic memory of inflammation, leading to heightened responses to future injury but also increased risk of relapse.
Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedMolecular Biology