Brooke R. Druliner

This study identifies maladaptive Piezo1 mechanotransduction as a driver of smooth muscle aging in the gut, showing it impairs contractility and contributes to gastrointestinal dysfunction.

This study shows that intestinal stem cells from IBD patients retain epigenetic memory of inflammation, leading to heightened responses to future injury but also increased risk of relapse.

The paper identifies genomic locations with altered nucleosome sensitivity that distinguish cancer-free from cancer-associated colon polyps and suggests their potential as biomarkers for early cancer detection.