Altered mRNA transport and local translation in iNeurons with RNA binding protein knockdown
Rachael Dargan, Alla Mikheenko, Nicholas L. Johnson, Benjamin Packer, Ziyi Li, Emma J. Craig, Stephanie L. Sarbanes, Colleen Bereda, Puja R. Mehta, Matthew J. Keuss, Mike A. Nalls, Yue Andy Qi, Cory A. Weller, Pietro Fratta, Veronica H. Ryan
This study investigates how knocking down RNA binding proteins affects mRNA transport and local translation in neurons, revealing distinct impacts on neuritic proteome and transcriptome.
bioRxiv · Sep 26, 2024 · PreprintNeuroscience