Modeling the critical MCOR-causing deletion in mouse unveils aberrant Sox21 expression in developing and adult iris and ciliary body, and implicates Tgfb2 in MCOR-associated glaucoma and myopia.
Clémentine Angée, Elisa Erjavec, Djihad Hadjadj, Bruno Passet, Pierre David, Corinne Kostic, Emmanuel Dodé, Xavier Zanlonghi, Nicolas Cagnard, Brigitte Nédelec, Sylvain Vincent Crippa, Christine Bôle‐Feysot, Mohammed Zarhrate, Sophie Creuzet, Johan Castille, , Lucas Fares‐Taie
The paper models a critical MCOR-causing deletion in mice, revealing aberrant Sox21 expression and implicating Tgfb2 in MCOR-associated glaucoma and myopia.
bioRxiv · Dec 11, 2023 · PreprintGenetics