Author

Johan Castille

AgroParisTechORCID 0000-0001-5388-9374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Bruno PassetiD· 4 shared Jean-Luc VilotteiD· 3 shared Nathalie Daniel-Carlier· 2 shared Alexandre Asset· 1 shared Andréa RauiD· 1 shared Béatrice Mandon‐PepiniD· 1 shared Brigitte NédeleciD· 1 shared Christine Bôle‐FeysotiD· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersGenetics

Bruno PassetORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintDec 11, 2023

Modeling the critical MCOR-causing deletion in mouse unveils aberrant Sox21 expression in developing and adult iris and ciliary body, and implicates Tgfb2 in MCOR-associated glaucoma and myopia.

Clémentine Angée, Elisa Erjavec, Djihad Hadjadj…·Lucas Fares‐Taie

The paper models a critical MCOR-causing deletion in mice, revealing aberrant Sox21 expression and implicating Tgfb2 in MCOR-associated glaucoma and myopia.

DOI 10.1101/2023.12.11.571097

mousestatistical model

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Molecular BiologybioRxivPreprintJun 1, 2023

Sixteen oogenesin genes are dispensable for fertilityWhat is the significance of the dispensability of genes expressed in germ-cell?

Johan Castille, Dominique Thépot, Sophie Fouchécourt…·Philippe Monget

The paper shows that deleting sixteen Oogenesin/Pramel family genes in mouse germ cells does not affect fertility, suggesting functional redundancy among paralogs.

DOI 10.1101/2023.06.01.543189

mouseexperimental assay

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GenomicsVeterinary ResearchPeer-reviewedJul 7, 2022

Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation

Andréa Rau, Bruno Passet, Johan Castille…·Jean-Luc Vilotte

The paper investigates the transcriptomic response of Prnp and Sprn double knockout mouse embryos to ShRNA lentiviral inoculation, finding reduced apoptosis and interferon responses in the double knockout compared to single knockouts.

2 citations

mousebulk RNA-seq

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Developmental BiologyFrontiers in Cell and Developmental BiologyPeer-reviewedJul 1, 2021

Topaz1, an essential gene for murine spermatogenesis, down-regulates the expression of numerous testis-specific long non-coding RNAs.

Manon Chadourne, Elodie Poumerol, Luc Jouneau…·Béatrice Mandon‐Pepin

This paper investigates the role of Topaz1 in murine spermatogenesis, showing it stabilizes testis-specific long non-coding RNAs and is critical for terminal differentiation but not essential for fertility.

12 citations

mousebulk RNA-seq

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