The phosphorylation status of LRRK2 at the S910/S935 cluster determines its sensitivity to activation by RAB29
Antonio Jesús Lara Ordóñez, Chloé Annicotte, Enna Behrends, Margaux Morez, Alessio Burin, Liesel Mary Goveas, Femke Van Mele, Christian Galicia, Wim Versées, Jean‐Marc Taymans
This study shows that dephosphorylation of LRRK2 at the S910/S935 cluster increases its sensitivity to activation by RAB29, leading to hyperactivation and centrosome cohesion deficits.
bioRxiv · May 26, 2026 · PreprintNeuroscience