Liesel Mary Goveas

This study investigates the uptake and release dynamics of gadoterate meglumine in white blood cells and K562 cells, showing active uptake and delayed Gd release via extracellular vesicles.

This study shows that dephosphorylation of LRRK2 at the S910/S935 cluster increases its sensitivity to activation by RAB29, leading to hyperactivation and centrosome cohesion deficits.

The paper identifies urinary protein signatures linked to LRRK2 dysfunction in Parkinson's disease using multi-cohort proteomics and machine learning, showing cross-species relevance and potential as pharmacodynamic markers.

The paper identifies two novel LRRK2 variants associated with familial Parkinson's disease and shows they alter phosphorylation and kinase activity.