PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis
Sravan Gopalkrishnashetty Sreenivasmurthy, Shaneilahi M. Budhwani, Sanjana Mohanty, Marlene E Villarreal, Poonam Shah, Shyny K John, Chandramouli Natarajan, Karthik Ramaswamy, Kyle Sheth, Enoch Wong, Phu Cuong Phan, Jose L Lopez, Satkarjeet Kaur Gill, Joshua Currie, Klarissa H Garza, , Balaji Krishnan
This study shows that modulating PLD1 affects synaptic integrity and cognition in aging and Alzheimer's disease models, with PLD1 attenuation improving synaptic function and memory in AD mice.
bioRxiv · Dec 11, 2025 · PreprintNeuroscience