Chronic fentanyl induces sex-specific anxiolytic-like effects in opioid-dependent rats
Lara S Caglayan, Fiona Zeyl, Enzo Gamba, Marcelo Febo, Adriaan W. Bruijnzeel
This study shows chronic fentanyl reduces anxiety-like behavior in opioid-dependent rats, with sex-specific effects, suggesting potential for misuse due to anxiolytic effects.
bioRxiv · Oct 23, 2026 · PreprintPharmacology & Toxicology