MuteFree: A novel AAV vector system featuring mutation-free ITRs
Silk J. Shi, Yingjun Lin, Epic Z. Fu, Hermia M. Xu, Robert J. Yang, Yaphia Y. Zhao, Jason Z. Ye, Jack F. Hong, Amy Y. Chen, Xingjian Bai, Bruce T. Lahn
MuteFree eliminates ITR mutations in AAV transfer plasmids, achieving 0% mutation rates and resolving production issues in GMP manufacturing.
bioRxiv · Apr 9, 2026 · PreprintMolecular Biology