An inducible genetic model of chronic hypoxic signaling in cardiomyocytes precipitates severe cardiomyopathy and remodeling.
Chelsea M. Phillips, Michael J. Zeitz, Eric Sapp, Karim M Abouelenein, James W. Smyth
This paper develops an inducible Vhl knockout mouse model to study chronic hypoxic stress in cardiomyocytes, revealing early gene expression changes linked to cardiac remodeling and disease.
bioRxiv · Apr 9, 2025 · PreprintPathology