Muscleblind-like proteins dimerize by forming disulfide bonds to regulate alternative splicing and pathogenic RNA foci formation
Luke A. Knudson, Adam Kosti, Ryan P. Hildebrandt, Ethan Jennings, Eric X Zhou, Kathryn R. Moss, Liang Shi, GiaLinh N. Nguyen, Aleksandra Janusz, Eric T. Wang, Gary Jonathan Bassell
This study identifies disulfide bonds mediating MBNL1 and MBNL2 dimerization, showing their role in alternative splicing regulation and RNA foci formation in myotonic dystrophy.
Nucleic Acids Research · May 20, 2026Peer-reviewedMolecular Biology