Ryan P. Hildebrandt

Muscleblind-like proteins dimerize by forming disulfide bonds to regulate alternative splicing and pathogenic RNA foci formation

This study identifies disulfide bonds mediating MBNL1 and MBNL2 dimerization, showing their role in alternative splicing regulation and RNA foci formation in myotonic dystrophy.

Transcriptome Alterations in Myotonic Dystrophy Frontal Cortex

The paper analyzes RNA-seq transcriptomes from frontal cortex tissue of DM1 and DM2 patients to identify splicing changes and their implications for CNS dysfunction.

ALS-linked SOD1 Mutants Enhance Outgrowth, Branching, and the Formation of Actin-Based Structures in Adult Motor Neurons

The paper shows that mutant SOD1 increases axonal outgrowth, dendritic branching, and actin-based structures in adult motor neurons from ALS mouse models, suggesting a potential therapeutic target.