Mistargeting of secretory cargo in retromer-deficient cells
Sarah D. Neuman, Erica L. Terry, Jane E. Selegue, Amy T. Cavanagh, Arash Bashirullah
The paper shows that retromer complex dysfunction leads to mistargeting of secretory cargo and accumulation of amyloid precursor protein in enlarged endosomes, linking retromer defects to neurodegenerative disease progression.
Disease Models & Mechanisms · Dec 29, 2020Peer-reviewedDevelopmental Biology