Single-cell transcriptomics reveals probiotic reversal of neonatal morphine-induced gene disruptions underlying adolescent pain hypersensitivity.
Junyi Tao, Danielle Antoine, Richa Jalodia, Eridania Valdes, Sean Michael Boyles, William F. Hulme, Sabita Roy
The paper uses single-cell RNA sequencing to show that neonatal morphine exposure disrupts midbrain gene expression in adolescent mice, but probiotic treatment reverses these effects.
Communications Biology · Dec 10, 2025Peer-reviewedNeuroscience