TCF7L2 is a master regulator of insulin production and processing
Yuedan Zhou, Soo-Young Park, Jing Su, Kathleen Bailey, Emilia Ottosson-Laakso, Liliya Shcerbina, Nikolay Oskolkov, Enming Zhang, Thomas Thevenin, Jo?o Fadista, Hedvig Bennet, Petter Vikman, Nils Wierup, Malin Fex, Johan Rung, , Ola Hansson
This study identifies TCF7L2-target genes and their regulatory network in insulin secretion, showing TCF7L2 regulates proinsulin synthesis, processing, and clearance in rodents and human islets.
bioRxiv · Mar 5, 2014Cell Biology