Author

Malin Fex

Lund UniversityORCID 0000-0003-0675-7576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Hindrik MulderiD· 4 shared Elaine CowaniD· 2 shared Luis Rodrigo CataldoiD· 2 shared Nils WierupiD· 2 shared Sevda GheibiiD· 2 shared A Hamilton· 1 shared Alexander Bowen· 1 shared Alexander HamiltoniD· 1 shared

Activity by Year

2014-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

Hindrik MulderORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the MTNR1B risk variant.

T. Singh, Sebastian Kalamajski, João Gabriel Dantas Cunha, Siarhei Hladkou, Fiona Louise Roberts, Sevda Gheibi, Anahita Soltanian, K. Yektay Farahmand, Ola Ekström, Anant Mamidi, Paul W. Franks, Anders H. Rosengren, Henrik Semb, Hindrik Mulder, Malin Fex

This study uses hiPSC and hESC to model the MTNR1B risk variant's effect on β-cell function, finding increased MTNR1B protein and melatonin sensitivity in G-allele carriers.

Journal of Pineal Research · Sep 1, 2025Peer-reviewedCell Biology

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and Signaling

Felipe Muñoz, Qian Gao, Matthias Mattanovich, Kajetan Trôst, Ondřej Hodek, Andreas Lindqvist, Nils Wierup, Malin Fex, Thomas Möritz, Hindrik Mulder, Luis Rodrigo Cataldo

This study shows lysine enhances insulin secretion through AASS-dependent catabolism, which regulates GABA content and mitochondrial function in beta cells.

bioRxiv · Mar 3, 2025 · PreprintCell Biology

DIMT1, a regulator of ribosomal biogenesis, controls beta-cell protein synthesis, mitochondrial function and insulin secretion

Gaurav Verma, Alexander Bowen, Sevda Gheibi, Alexander Hamilton, Sowndarya Muthukumar, Luis Rodrigo Cataldo, Olof Asplund, Jonathan L.S. Esguerra, Alexandros Karagiannopoulos, Claire Lyons, Elaine Cowan, Cristian Bellodi, Rashmi B. Prasad, Malin Fex, Hindrik Mulder

This study identifies DIMT1 as a regulator of ribosomal biogenesis in beta-cells, showing its role in mitochondrial function and insulin secretion, with implications for type 2 diabetes.

Journal of Biological Chemistry · Feb 8, 2022Peer-reviewedMolecular Biology

Mitochondrial clearance of Ca2+ controls insulin secretion

Neelanjan Vishnu, A Hamilton, Annika Bagge, Anya Wernersson, Elaine Cowan, H Barnard, Yasemin Sancak, Kimberli J. Kamer, Peter Spégel, Malin Fex, Anders Tengholm, Vamsi Krishna Mootha, D.G. Nicholls, Hindrik Mulder

This study shows that mitochondrial Ca2+ clearance regulates insulin secretion by modulating plasma membrane Ca2+ entry in beta-cells.

bioRxiv · Nov 5, 2019 · PreprintMolecular Biology

TCF7L2 is a master regulator of insulin production and processing

Yuedan Zhou, Soo-Young Park, Jing Su, Kathleen Bailey, Emilia Ottosson-Laakso, Liliya Shcerbina, Nikolay Oskolkov, Enming Zhang, Thomas Thevenin, Jo?o Fadista, Hedvig Bennet, Petter Vikman, Nils Wierup, Malin Fex, Johan Rung, , Ola Hansson

This study identifies TCF7L2-target genes and their regulatory network in insulin secretion, showing TCF7L2 regulates proinsulin synthesis, processing, and clearance in rodents and human islets.

bioRxiv · Mar 5, 2014Cell Biology