Ola Hansson

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

This study shows exercise training reduces epigenetic and transcriptomic aging in human skeletal muscle, while muscle disuse accelerates transcriptomic aging.

Islet Gene View - a tool to facilitate islet research

The paper introduces Islet Gene View (IGW), a platform that integrates gene expression and phenotypic data from pancreatic islets to explore T2D-related gene expression changes and their functional implications.

Influence of genetic variants on gene expression in human pancreatic islets - implications for type 2 diabetes

The paper investigates how genetic variants affect gene expression in human pancreatic islets and identifies candidate genes linked to type 2 diabetes.

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

Turning vice into virtue: Using Batch-Effects to Detect Errors in Large Genomic Datasets

The paper detects systematic errors in large genomic datasets by analyzing batch effects, finding coding regions have more errors than non-coding regions.

TCF7L2 is a master regulator of insulin production and processing

This study identifies TCF7L2-target genes and their regulatory network in insulin secretion, showing TCF7L2 regulates proinsulin synthesis, processing, and clearance in rodents and human islets.