Empagliflozin targets a renal neuro-epithelial-immune axis in heart failure
Jennifer N. Coelho, Livia C. Simonete, João Carlos Ribeiro-Silva, Erika F. Jesus, Andreia Boaro, Flavia L. Martins, José Wilson do Nascimento Corrêa, Larissa Ferreira dos Santos, Danúbia Silva dos Santos, Ednei Luiz Antônio, Raphael E. Szawka, Andrey Jorge Serra, Adriana C. C. Girardi
Empagliflozin lowered renal norepinephrine by about 50% in rats with heart failure, independent of intrarenal renin-angiotensin activity, and shifted kidney macrophages toward a reparative phenotype.
American Journal of Physiology-Cell Physiology · May 12, 2026Peer-reviewedPhysiology✦ In-depth digest