PhysiologyAmerican Journal of Physiology-Cell PhysiologyPeer-reviewed
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Empagliflozin targets a renal neuro-epithelial-immune axis in heart failure
Jennifer N. Coelho, Livia C. Simonete, João Carlos Ribeiro-Silva…·Adriana C. C. Girardi
Empagliflozin lowered renal norepinephrine by about 50% in rats with heart failure, independent of intrarenal renin-angiotensin activity, and shifted kidney macrophages toward a reparative phenotype.