CD8+ T cells mediate vaccination-induced lymphatic containment of latent Mycobacterium tuberculosis infection following immunosuppression, while B cells are dispensable
Socorro Miranda‐Hernandez, Manoharan Kumar, Alec S. Henderson, Erin Graham, Xiao Tan, Jim Taylor, Michael T. Meehan, Zuriel Ceja, Lidia del Pozo-Ramos, Yi Pan, Ellen Tsui, Meg L. Donovan, Miguel E. Rentería, Mario Alberto Flores‐Valdez, Antje Blumenthal, , Andreas Kupz
This study shows that CD8+ T cells prevent reactivation of latent Mtb infection after immunosuppression, while B cells are not required for this protection.
bioRxiv · Jan 23, 2025 · PreprintImmunology