Socorro Miranda‐Hernandez

This paper describes an mRNA-based prime-and-pull vaccination strategy that combines subcutaneous BCG vaccination with mucosal mRNA delivery to achieve protective immunity against tuberculosis with improved safety.

This study shows that pulmonary delivery of ESAT-6-secreting BCG strains improves safety and protection against TB in immunocompromised mice, independent of adaptive immunity.

This study shows that mucosal BCG vaccination induces lung CD8+ TRM cells via TGF-β activation by airway epithelial progenitors, linking tissue repair to immune memory.

This study shows that CD8+ T cells prevent reactivation of latent Mtb infection after immunosuppression, while B cells are not required for this protection.

This paper develops a modular peptide nanoparticle vaccine platform that enhances BCG's immunogenicity and efficacy in a murine TB model by over 5-fold.