Andreas Kupz

Malnourishment and expanded microbiome maintain superior efficacy of the recombinant tuberculosis vaccine BCG::ESAT-6-PE25SS

This study shows that malnourishment and microbiome changes enhance the efficacy of a recombinant BCG TB vaccine in mice, linking diet, microbiota, and immune responses to TB protection.

mRNA-based prime-and-pull vaccination combines benefits of subcutaneous and mucosal BCG vaccination

This paper describes an mRNA-based prime-and-pull vaccination strategy that combines subcutaneous BCG vaccination with mucosal mRNA delivery to achieve protective immunity against tuberculosis with improved safety.

Pulmonary delivery of antigen-enhanced BCG overcomes safety barriers in immunocompromised hosts and protects against TB in the absence of adaptive immunity.

This study shows that pulmonary delivery of ESAT-6-secreting BCG strains improves safety and protection against TB in immunocompromised mice, independent of adaptive immunity.

Lung epithelial progenitor-mediated release of TGF-β regulates induction and persistence of lung CD8+ TRM cells following mucosal BCG vaccination

This study shows that mucosal BCG vaccination induces lung CD8+ TRM cells via TGF-β activation by airway epithelial progenitors, linking tissue repair to immune memory.

CD8+ T cells mediate vaccination-induced lymphatic containment of latent Mycobacterium tuberculosis infection following immunosuppression, while B cells are dispensable

This study shows that CD8+ T cells prevent reactivation of latent Mtb infection after immunosuppression, while B cells are not required for this protection.

A modular self-assembling and self-adjuvanting multiepitope peptide nanoparticle vaccine platform to improve the efficacy and immunogenicity of BCG

This paper develops a modular peptide nanoparticle vaccine platform that enhances BCG's immunogenicity and efficacy in a murine TB model by over 5-fold.