Advancing quality-control for NGS measurement of actionable mutations in circulating tumor DNA
James C. Willey, Tom Morrison, Brad Austermiller, Erin L. Crawford, Daniel J. Craig, Thomas M. Blomquist, Wendell D. Jones, Aminah Wali, Jennifer S. Lococo, Nathan Haseley, Todd A. Richmond, Natalia Novoradovskaya, Rebecca L. Kusko, Guangchun Chen, Quan-Zhen Li, , Joshua Xu
This paper develops a targeted NGS method with synthetic internal standards to improve detection of actionable mutations in ctDNA, increasing sensitivity and enabling quality control metrics.
bioRxiv · Apr 6, 2021 · PreprintGenomics