Joshua Xu

This study identifies MBD1-L, an aberrantly spliced transcript in MDS, which drives epigenetic changes leading to myeloerythroid defects, and shows ASO-based targeting can restore erythroid differentiation.

This study compares the virulence of Zika and Dengue viruses by analyzing host mRNA processing factors and identifies differences in their impact on host cell cytopathic effects.

This paper introduces Quartet DNA reference materials to comprehensively evaluate germline variant calling accuracy across the genome, including difficult regions and batch effects.

The paper evaluates seven batch-effect correction algorithms for multiomic data and finds the ratio-based method is more effective, especially when batch effects are confounded with biological factors.

This paper introduces ratio-based multiomics profiling using universal reference materials to improve data integration across omics types and batches.

The paper introduces RNA reference materials and ratio-based datasets to improve the reliability and benchmarking of transcriptomic profiling.

This paper characterizes the ZMYND11-MBTD1 fusion protein's role in oncogenesis by mislocalizing the NuA4/TIP60 complex to gene bodies, altering transcription and splicing, particularly of the MYC oncogene.

This paper develops a targeted NGS method with synthetic internal standards to improve detection of actionable mutations in ctDNA, increasing sensitivity and enabling quality control metrics.

The paper evaluates epigenetic methods using reference materials, finding high concordance between assays and differences in performance across platforms.