Author

Guangchun Chen

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Adil R. KhaniD· 1 shared Afeefah Khazi-SyediD· 1 shared Aminah Wali· 1 shared Andrew R. JamiesoniD· 1 shared Angela Fan· 1 shared Brad Austermiller· 1 shared Chengsong ZhuiD· 1 shared Cheryl M. LewisiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBioengineering

Adil R. KhanORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early-Onset Colorectal Cancer

Nicole C. Huning, Munir H. Buhaya, Victor Nguyen, Afeefah Khazi-Syed, Haider Ali, Adil R. Khan, Angela Fan, Robert C. Fisher, Zhikai Chi, Indu Raman, Guangchun Chen, Chengsong Zhu, Mengxi Yu, Andrew R. Jamieson, Sara Roccabianca, , Jacopo Ferruzzi

This study identifies biomechanical stiffening and fibrotic remodeling as hallmarks of early-onset colorectal cancer, showing their role in tumor initiation.

Advanced Science · Dec 1, 2025Peer-reviewedBioengineering

Advancing quality-control for NGS measurement of actionable mutations in circulating tumor DNA

James C. Willey, Tom Morrison, Brad Austermiller, Erin L. Crawford, Daniel J. Craig, Thomas M. Blomquist, Wendell D. Jones, Aminah Wali, Jennifer S. Lococo, Nathan Haseley, Todd A. Richmond, Natalia Novoradovskaya, Rebecca L. Kusko, Guangchun Chen, Quan-Zhen Li, , Joshua Xu

This paper develops a targeted NGS method with synthetic internal standards to improve detection of actionable mutations in ctDNA, increasing sensitivity and enabling quality control metrics.

bioRxiv · Apr 6, 2021 · PreprintGenomics