Erin L. Edgar

Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test

This study shows that morphine exposure during adolescence affects social behavior differently based on sex and the stage of exposure, with lasting effects on adult sociability.

Impaired microglia-mediated synaptic pruning in the nucleus accumbens during adolescence results in persistent dysregulation of familiar, but not novel social interactions in sex-specific ways

Social aging trajectories are sex-specific, sensitive to adolescent stress, and most robustly revealed during social tests with familiar stimuli

The paper investigates sex-specific social aging in rats, showing that adolescent stress impacts social behavior differently in males and females, with effects most evident during social tests involving familiar stimuli.