The paper investigates how adolescent microglial synaptic pruning in the nucleus accumbens sex-specifically affects splenic immune outcomes through proteomic analysis.

DOI 10.1101/2023.05.03.539317

ratproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 2, 2023

Impaired microglia-mediated synaptic pruning in the nucleus accumbens during adolescence results in persistent dysregulation of familiar, but not novel social interactions in sex-specific ways

Julia M. Kirkland, Erin L. Edgar, Ishan Patel, Ashley M. Kopec

5 citations

ratexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 27, 2023

Social aging trajectories are sex-specific, sensitive to adolescent stress, and most robustly revealed during social tests with familiar stimuli

Christopher Figueroa, Erin L. Edgar, Julia M. Kirkland…·Ashley M. Kopec

The paper investigates sex-specific social aging in rats, showing that adolescent stress impacts social behavior differently in males and females, with effects most evident during social tests involving familiar stimuli.

1 citation

ratexperimental assay

𝕏 PostBluesky