Ernesto A. Roman

Amino acid clustering and epistasis guide sequence-based prediction of phenotype modulation

The paper develops a method to predict phenotype modulation by analyzing amino acid clustering and epistasis in protein sequences, showing that these factors improve prediction accuracy.

Cracking Controls ATP Hydrolysis in the catalytic unit of a P-type ATPase

The paper investigates how ATP hydrolysis in the catalytic unit of a P-type ATPase is controlled through conformational changes, revealing a 'cracking'-like mechanism.