Peter Guy Wolynes

CaMKII generates actin bundle morphology and mechanics distinct from canonical bivalent cross-linkers

This study compares the structural and mechanical properties of actin bundles formed by CaMKII with those formed by canonical cross-linkers, revealing unique flexibility and curvature in CaMKII bundles.

Cracking Controls ATP Hydrolysis in the catalytic unit of a P-type ATPase

The paper investigates how ATP hydrolysis in the catalytic unit of a P-type ATPase is controlled through conformational changes, revealing a 'cracking'-like mechanism.

Real-Time Visualization of Protein Microenvironment Changes with High Spatial Resolution in Live Cells via Site-Specific Incorporation of Rotor-Based Fluorescent Noncanonical Amino Acids

This study develops a method to visualize protein microenvironment changes in live cells using rotor-based fluorescent noncanonical amino acids incorporated at specific sites.

DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins

This study investigates how DNA polymerase displaces SSBs during replication, showing sequential displacement and the role of SSB saturation in replication efficiency.

Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample

This paper reports the 3D genome architecture of a 52,000-year-old woolly mammoth using a novel method, revealing conserved epigenetic features across elephantids.

Frustraevo: A Web Server To Localize And Quantify The Conservation Of Local Energetic Frustration In Protein Families

FrustraEvo calculates and quantifies the conservation of local energetic frustration in protein families to identify evolutionary stability and functional constraints.

The Evolution of Local Energetic Frustration in Protein Families

The paper analyzes local energetic frustration in protein families to uncover stability and function constraints, demonstrating its application to SARS-CoV-2 and poorly characterized proteins.

Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues

The paper uses physical simulations to study the 3D genome architecture of Aedes aegypti, revealing liquid crystalline structures and sensitivity to nuclear deformation.

A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines

This paper proposes a computational model showing how CPEB3-SUMO2 interactions regulate translational control in dendritic spines by shifting mRNA binding equilibrium.

Unleashing the Potential of Noncanonical Amino Acid Biosynthesis for Creation of Cells with Site-Specific Tyrosine Sulfation

This paper reports the creation of autonomous cells capable of biosynthesizing and genetically encoding sulfotyrosine, enabling site-specific protein sulfation with higher efficiency than exogenous feeding.

FrustratometeR: an R-package to compute Local frustration in protein structures, point mutants and MD simulations

FrustratometeR computes local energetic frustration in protein structures, point mutants, and MD simulations for structural analysis.

Frustration in protein complexes leads to interaction versatility

The paper shows that disordered proteins in fuzzy complexes retain residual frustration, leading to interaction versatility with different partners.

OpenAWSEM with Open3SPN2: a fast, flexible, and accessible framework for large-scale coarse-grained biomolecular simulations

This paper introduces OpenAWSEM and Open3SPN2, GPU-accelerated coarse-grained simulation tools for proteins and DNA, enabling faster and more flexible modeling of biomolecular systems.

The Nucleome Data Bank: Web-based Resources to Simulate and Analyze the Three-Dimensional Genome

The paper introduces the Nucleome Data Bank, a web-based platform for simulating and analyzing the 3D genome using epigenetic data, and provides tools for visualization and data analysis.