Acquisition of specific human respiratory tract binding of 2.3.4.4b H5N1 hemagglutinins requires multiple mutations
María Ríos Carrasco, Mafalda F Guerreiro Cabana, Eszter Kovacs, Zoé Ducarne, Cindy G. J. Cleypool, Geert‐Jan Boons, Robert P. de Vries
This study shows that multiple mutations, not just Q226L, are required for H5N1 hemagglutinin to bind human respiratory tract tissue, highlighting the complexity of receptor specificity evolution.
Journal of Virology · Aug 10, 2026Peer-reviewedMicrobiology