Theoretical basis for stabilizing messenger RNA through secondary structure design
H. K. Wayment-Steele, D. S. Kim, C. A. Choe, J. J. Nicol, R. Wellington-Oguri, A. M. Watkins, R. A. Parra Sparberg, P. Huang, Eterna Massive Open Laboratory, R. Das
This paper develops a biophysical model to predict RNA stability and demonstrates that superfolder mRNAs can increase in vitro half-life by at least two-fold through AUP optimization.
bioRxiv · Aug 22, 2020Biophysics