BiophysicsbioRxiv
Theoretical basis for stabilizing messenger RNA through secondary structure design
H. K. Wayment-Steele, D. S. Kim, C. A. Choe…·R. Das
This paper develops a biophysical model to predict RNA stability and demonstrates that superfolder mRNAs can increase in vitro half-life by at least two-fold through AUP optimization.
DOI 10.1093/nar/gkab764