Author

H. K. Wayment-Steele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 4 Approach:statistical model· 3 Research Focus:sequence-to-function modeling· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:graph neural network· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

R. Das· 2 shared A. Ho· 1 shared A. I. Strom· 1 shared A. M. Watkins· 1 shared A. Treuille· 1 shared C. A. Choe· 1 shared D. Kern· 1 shared D. S. Kim· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

R. Das

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Author profile →

4 papers

Recent·Most cited

High-Throughput DNA melt measurements enable improved models of DNA folding thermodynamics

Y. Ke, E. Sharma, H. K. Wayment-Steele, W. R. Becker, A. Ho, E. Marklund, W. J. Greenleaf

This paper introduces a high-throughput method to measure DNA melting and develops models to improve DNA folding thermodynamics predictions.

bioRxiv · Jan 8, 2024Biophysics

Prediction of multiple conformational states by combining sequence clustering with AlphaFold2

H. K. Wayment-Steele, S. Ovchinnikov, L. Colwell, D. Kern

The paper uses sequence clustering with AlphaFold2 to predict conformational states of proteins and identifies mutations that switch between states.

bioRxiv · Oct 17, 2022 · PreprintBiochemistry

Theoretical basis for stabilizing messenger RNA through secondary structure design

H. K. Wayment-Steele, D. S. Kim, C. A. Choe, J. J. Nicol, R. Wellington-Oguri, A. M. Watkins, R. A. Parra Sparberg, P. Huang, Eterna Massive Open Laboratory, R. Das

This paper develops a biophysical model to predict RNA stability and demonstrates that superfolder mRNAs can increase in vitro half-life by at least two-fold through AUP optimization.

bioRxiv · Aug 22, 2020Biophysics

RNA secondary structure packages evaluated and improved by high-throughput experiments

H. K. Wayment-Steele, W. Kladwang, A. I. Strom, J. Lee, A. Treuille, Eterna Participants, R. Das

The paper evaluates RNA structure prediction packages using synthetic data and introduces an improved model that performs better on diverse datasets.

bioRxiv · May 29, 2020 · PreprintBiophysics