The Primary Cilium and its Hedgehog Signaling in Nociceptors Contribute to Inflammatory and Neuropathic Pain
Lindsey Avery Fitzsimons, Larissa Staurengo‐Ferrari, Oliver Bogen, Dionéia Araldi, Ivan J. M. Bonet, Ethan E Jordan, Jon D. Levine, Kerry Lee Tucker
This study shows that primary cilia in nociceptors modulate mechanical nociception and contribute to inflammatory and neuropathic pain, with Hedgehog signaling playing a role in neuropathic pain.
bioRxiv · Dec 27, 2023 · PreprintNeuroscience