Jon D. Levine

The paper shows that low-dose morphine directly sensitizes human and rat nociceptors via TLR4, contributing to opioid-induced hyperalgesia.

This paper demonstrates that IB4-conjugated streptavidin can selectively knock down PKCε in IB4+ nociceptors, reversing hyperalgesic priming in a chronic pain model.

This study shows that primary cilia in nociceptors modulate mechanical nociception and contribute to inflammatory and neuropathic pain, with Hedgehog signaling playing a role in neuropathic pain.

This study investigates the NGFR100W mutation in NGF, showing it supports neuronal survival via TrkA but fails to activate p75NTR, distinguishing trophic from nociceptive signaling.