Monitoring mutant myocilin secretion and localization in trabecular meshwork cell cultures using a protein complementation-based luminescence assay
Hannah A. Youngblood, Ethan F. Harris, Kaylee P. Lankford, Victoria Garfinkel, John D. Hulleman, Raquel L. Lieberman
This paper introduces a luminescence assay to detect myocilin secretion defects in trabecular meshwork cells and confirms secretion issues for several mutant variants.
Experimental Eye Research · Mar 3, 2025Peer-reviewedBiochemistry