Subcellular spatiotemporal proteomics delineates distinct phases of ER stress proteostatic response
Lorena Alamillo, Thalia Paiz, Alexander Black, Matthew C. Juber, Ethan M. Arends, Jacob G. Cox, Dominic C M Ng, Timothy A. McKinsey, Maggie P. Y. Lam, Edward Lau
This study uses SPLAT-TR to analyze proteome changes in ER stress, revealing distinct temporal phases of protein translocation, clearance, and degradation in different organelles.
bioRxiv · Sep 28, 2026 · PreprintBiochemistry