An internal disulfide locks a misfolded aggregation-prone intermediate in cataract-linked mutants of human γD-crystallin
Eugene Serebryany, Jaie C. Woodard, Bharat V. Adkar, Mohammed Shabab, Jonathan A. King, Eugene I. Shakhnovich
The paper investigates how an internal disulfide bond stabilizes a misfolded intermediate in cataract-linked γD-crystallin mutants, leading to amorphous aggregation.
Journal of Biological Chemistry · Sep 1, 2016Peer-reviewedBiophysics