Organelle-Aware Representation Learning Enables Label-Free Detection of Mitochondrial Dysfunction in Live Human Neurons
SeungJu Yoo, Eunjin Yang, Seohyun Kim, Hoewon Park, Daesoo Kim, Ki‐Jun Yoon, Minee L. Choi
This paper introduces a noninvasive framework using optical diffraction tomography and organelle-aware representation learning to detect mitochondrial dysfunction in live human neurons with high accuracy.
bioRxiv · Oct 12, 2025 · PreprintNeuroscience