Chromatoid body integrates piRNA, SMG6 and m⁶A pathways to control mRNAs in the male germline
Ammar Ahmedani, Eva Savulkina, Lin Ma, Simang Champramary, Alessia Di Pauli, Elina Valkonen, Samuli OM Laasanen, Riikka Palimo, Ruben Aju George, Keshav Thapa, Tiina Lehtiniemi, Ann‐Kristin Dicke, Sabine Kliesch, Nina Neuhaus, Birgit Stallmeyer, , Noora Kotaja
The paper shows SMG6 and PIWIL1 work together in the chromatoid body to regulate mRNAs via piRNA and NMD pathways, with SMG6's endonuclease activity aiding piRNA-guided degradation.
bioRxiv · Mar 28, 2026 · PreprintCell Biology