Nina Neuhaus

This study creates a single-nucleus multiomic and spatial atlas of human spermatogenesis, linking gene regulatory networks to infertility-associated genetic variation and disease perturbations.

This study identifies transcriptional states and regulators of spermatogonial stem cell differentiation in marmoset testes across developmental stages.

The paper shows SMG6 and PIWIL1 work together in the chromatoid body to regulate mRNAs via piRNA and NMD pathways, with SMG6's endonuclease activity aiding piRNA-guided degradation.

This study uses long-read sequencing to analyze gene conversion and crossover events in human, chimpanzee, and gorilla testes and sperm, revealing species-specific patterns and GC bias in gene conversion.

This study identifies genome-wide DNA methylation changes during human spermatogenesis and their disruption in disturbed spermatogenesis, highlighting hypomethylation at specific regions and transposable elements.

The paper identifies genotype-specific meiotic impairments in infertile men with loss-of-function variants in M1AP or ZZS genes, showing different recombination failures and reproductive outcomes.

The paper analyzes transcriptomes of human testis with different germ cell arrest stages to identify gene and transcript dynamics during spermatogenesis.

The paper identifies EGR4-dependent UTF1 downregulation as a factor in reduced reserve spermatogonial stem cells in infertile men, linked to altered chromatin structure.

This study shows TRIM71 is essential for germ cell development in mice and links TRIM71 variants to human male infertility.

The paper identifies biallelic M1AP mutations as a cause of meiotic arrest and male infertility through whole exome sequencing and cohort screening.

The paper investigates DNA methylation patterns in sperm from infertile men and finds that somatic DNA contamination and genetic variation, rather than recurrent epimutations, explain observed methylation abnormalities.