NeurosciencebioRxivPreprint
Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
Marián Hruška-Plocháň, Katharina M. Betz, Silvia Ronchi…·Magdalini Polymenidou
The paper develops a human iPSC-derived neural model to study TDP-43 pathology, identifying NPTX2 misregulation as a key factor in ALS/FTLD neurotoxicity.