Dáša Bohačiaková

From Patient to Tumor Organoid: Culture Protocol Choice Controls Glioblastoma Tumor Architecture and Identity

This study compares fragment-based and dissociation-based protocols for culturing glioblastoma organoids, finding that fragment-based methods better preserve tumor biology and extracellular matrix features.

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction

This study uses patient-derived cerebral organoids to show that amyloid-β dysregulation correlates with network hyperexcitability in early Alzheimer's disease.

Taurine Inhibits Apolipoprotein E4 Aggregation

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants.

The paper measures soluble SORL1 (sSORL1) in CSF to assess functional impact of rare SORL1 variants, finding lower sSORL1 in carriers of pathogenic variants.

The Alzheimer's-Associated SORL1 p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models

This study investigates the effects of the SORL1 p.Y1816C variant on neuronal function using iPSC-derived models, showing impaired SORLA maturation, altered APP processing, and disrupted axonal transport and electrophysiology.

Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models

This study shows HSV-1 infection induces Aβ clustering and neurodegeneration pathways in iPSC-derived neurons, supporting the pathogen infection hypothesis for Alzheimer's disease.

Apolipoprotein-based regulation of ganglioside metabolism upon secretase activity inhibition in iPSC-derived cerebral organoids

This study investigates how secretase inhibitors affect ganglioside metabolism in iPSC-derived cerebral organoids with ApoE3 and ApoE4 variants, showing increased ganglioside and ceramide levels in ApoE4 organoids.

Domino-like Effect of C112R Mutation on APOE4 Aggregation and Its Reduction by Alzheimer's Disease Drug Candidate

The paper investigates how the C112R mutation in ApoE4 causes aggregation and shows that tramiprosate reduces this aggregation.

Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD

The paper develops a human iPSC-derived neural model to study TDP-43 pathology, identifying NPTX2 misregulation as a key factor in ALS/FTLD neurotoxicity.